I am giving this supplement to a family member with osteoarthritis. This is part of a Naturopathic Doctor's prescribed and recommended protocol and it helped first to reduce symptoms, then after taking it for several months we can see the start of reversal back to healthy joints. While I believe the success with this is due to the synergy with the other products in the protocol but at one point we ran out of Imm-Kine and the rest of the products did not have the same positive effect, so there was a noted positive difference with Imm-Kine. We now make sure to always order this before we run out.